Autoregulation of dynamic cerebral blood flow during hypotensive anesthesia with prostaglandin E1 or nitroglycerin

Autoregulation of dynamic cerebral blood flow during hypotensive anesthesia is unclear. We examined the effects of hypotensive anesthesia with prostaglandin E1 (PGE1) or nitroglycerin (NTG) on autoregulation of the dynamic cerebral blood flow. Beat-by-beat mean arterial pressure (MAP) and blood flow...

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Bibliographic Details
Published inMasui. The Japanese journal of anesthesiology Vol. 53; no. 4; p. 376
Main Authors Kubota, Naoto, Iwasaki, Ken-ichi, Ishikawa, Hisashi, Shiozawa, Tomoki, Kato, Jitsu, Ogawa, Setsuro
Format Journal Article
LanguageJapanese
Published Japan 01.04.2004
Subjects
Adult
Alprostadil - pharmacology
Anesthesia, General
Cerebrovascular Circulation - drug effects
Homeostasis - drug effects
Humans
Hypotension, Controlled
Middle Aged
Nitroglycerin - adverse effects
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Summary:Autoregulation of dynamic cerebral blood flow during hypotensive anesthesia is unclear. We examined the effects of hypotensive anesthesia with prostaglandin E1 (PGE1) or nitroglycerin (NTG) on autoregulation of the dynamic cerebral blood flow. Beat-by-beat mean arterial pressure (MAP) and blood flow velocity in the middle cerebral artery were measured before and during hypotensive anesthesia. The relationship between changes in MAP and cerebral blood flow velocity was evaluated by using the method of transfer function analysis. We calculated transfer function gain and coherence by cross-spectrum from autospectra of MAP and blood flow velocity in the low (0.07-0.2 Hz) and high (0.2-0.3 Hz) frequency ranges. The gain in the both frequency ranges was unchanged during hypotensive anesthesia with PGE1. During hypotensive anesthesia with NTG, the gain in the high frequency range was unchanged, either. However, the gain in the low frequency range increased during hypotensive anesthesia with NTG. The value was significantly higher than in hypotensive anesthesia with PGE1. These results suggest that hypotensive anesthesia with PGE1 maintains autoregulation of the dynamic cerebral blood flow, but NTG impairs the autoregulation in the low frequency range.
ISSN:0021-4892