Effect of brahma rasayana on antioxidant system after radiation

Oral administration of brahma rasayana (BR; 50 mg/animal for 10 and 30 days) significantly increased the liver antioxidant enzymes such as superoxide dismutase (SOD), catalase(CAT) and tissue and serum levels of reduced glutathione (GSH). Whole body irradiation suppressed the levels of SOD, CAT and...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 39; no. 11; p. 1173
Main Authors Rekha, P S, Kuttan, G, Kuttan, R
Format Journal Article
LanguageEnglish
Published India 01.11.2001
Subjects
Animals
Antioxidants - pharmacology
Catalase - metabolism
Chemotherapy, Adjuvant
Glutathione - metabolism
Liver - drug effects
Liver - metabolism
Liver - radiation effects
Mice
Phytotherapy
Plant Extracts - pharmacology
Radiation Injuries, Experimental - prevention & control
Superoxide Dismutase - metabolism
Whole-Body Irradiation
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Summary:Oral administration of brahma rasayana (BR; 50 mg/animal for 10 and 30 days) significantly increased the liver antioxidant enzymes such as superoxide dismutase (SOD), catalase(CAT) and tissue and serum levels of reduced glutathione (GSH). Whole body irradiation suppressed the levels of SOD, CAT and GSH. Reduced activity of SOD, CAT and GSH was significantly elevated by treatment with BR after radiation treatment. Similarly radiation exposure induced increase in serum and liver lipid peroxides was significantly reduced by further treatment with BR. The results indicate that BR could ameliorate the oxidative damage produced in the body by radiation and may be useful as an adjuvant during radiation therapy.
ISSN:0019-5189