Association analysis between attention-deficit hyperactivity disorder and Val158Met polymorphism of catechol-O-methyltransferase gene

• Published in: Zhonghua yi xue yi chuan xue za zhi Vol. 20; no. 4; p. 322
• Main Authors: Zhang, Xian-ning, Ruan, Lie-min, Le, Yan-ping, Zhang, Ye
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2003
• Subjects: Adolescent; Attention Deficit Disorder with Hyperactivity - enzymology; Attention Deficit Disorder with Hyperactivity - genetics; Catechol O-Methyltransferase - genetics; Child; Exons - genetics; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide
• ISSN: 1003-9406

To investigate the association between attention-deficit hyperactivity disorder (ADHD) in Han Chinese children and Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene caused by the missense mutation of G158A in exon 4. By using polymerase chain reaction-restriction fragment length polymorphisms the Val158Met polymorphism of COMT gene was tested in 117 children with the diagnosis of ADHD as defined by DSM-IV and in 105 healthy controls living in Shanghai. The frequencies of A allele were 25.21% and 23.81% in the ADHD group and the health controls respectively, which showed no significant difference between the two groups (Chi2=0.5197, P>0.05). There was also no significant difference in the distribution of all genotypes of COMT gene between the ADHD patients and the controls (P>0.05). It was suggested that for the Han Chinese children with ADHD in this study, there was no association between ADHD and Val158Met polymorphism of COMT gene.