Impact of hypercholesterolemia on in vitro toxicity of N-nitrosodiethylamine: effect on lipidperoxidation of blood and tissue

In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic poten...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 40; no. 9; p. 1071
Main Authors Mittal, Gaurav, Kaur, Manpreet, Soni, Giridhar
Format Journal Article
LanguageEnglish
Published India 01.09.2002
Subjects
Alkylating Agents - toxicity
Animals
Dietary Supplements
Diethylnitrosamine - toxicity
Erythrocytes - drug effects
Heart - physiology
Hypercholesterolemia - blood
In Vitro Techniques
Kidney - metabolism
Lipid Peroxidation - drug effects
Liver - metabolism
Lung - metabolism
Male
Osmotic Fragility - drug effects
Rats
Spleen - metabolism
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Summary:In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic potential as evidenced by insignificant effect on lipid peroxidation (LPO). However, (LPO) of all the tissues (heart, lung, liver, kidney and spleen) increased significantly on in vitro treatment with NDEA. The effects were different in different tissues under different dietary conditions
ISSN:0019-5189
0975-1009