Effect of superoxide dismutase on membrane fluidity and functions of lymphocytes in traumatized mice

Effect of superoxide dismutase (SOD) on membrane fluidity and functions of lymphocytes in traumatized mice was studied. The results showed that in vivo administration of SOD (10,000 U/kg.d, from 0 to 3 days posttrauma) could significantly decrease malondialdehyde (MDA) contents in serum, lymphatic t...

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Published inZhongguo ying yong sheng li xue za zhi Vol. 13; no. 4; p. 309
Main Authors Luo, Y, Liang, H, Wang, Z, Geng, B, Xu, X
Format Journal Article
LanguageChinese
Published China 01.11.1997
Subjects
Animals
Cell Membrane
Female
Free Radical Scavengers - pharmacology
Hindlimb - injuries
Male
Membrane Fluidity - drug effects
Mice
Mice, Inbred BALB C
Random Allocation
Superoxide Dismutase - pharmacology
T-Lymphocytes - immunology
Wounds, Nonpenetrating - immunology
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Summary:Effect of superoxide dismutase (SOD) on membrane fluidity and functions of lymphocytes in traumatized mice was studied. The results showed that in vivo administration of SOD (10,000 U/kg.d, from 0 to 3 days posttrauma) could significantly decrease malondialdehyde (MDA) contents in serum, lymphatic tissues from spleen, thymus, mesenteric lymph nodes and T cells plasmalemma, mitochondria, microsome, restore decreased T lymphocytes and T cells in traumatized mice, elevate membrane fluidity of lymphocytes transformation (TLT), reduce interleukin 2 (IL-2) production, supprssed IL-2 receptor (IL-2R) expression and depress IL-2 mediated lymphocyte proliferation response (IL 2MLPR) after trauma in various degress. It is suggested that SOD may protect lymphocytes post trauma from damage of oxygen free radical, and elevate lymphocytes functions.
ISSN:1000-6834