Induction of MGE 412 transposition in an isogenic strain of Drosophila melanogaster by different doses of ethanol fumes

• Published in: Genetika Vol. 39; no. 5; p. 717
• Main Authors: Vasil'eva, L A, Ratner, V A, Antonenko, O V, Lopukhova, E D, Bubenshchikova, E V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.05.2003
• Subjects: Animals; DNA Transposable Elements - drug effects; Dose-Response Relationship, Drug; Drosophila melanogaster - genetics; Ethanol - pharmacology; Gene Expression Regulation - drug effects; Genetic Variation; Male; Time Factors
• ISSN: 0016-6758

The effect of treatment of males from an isogenic Drosophila melanogaster strain by limiting doses of ethanol fumes on transpositions of MGE 412 was examined. Validity of the phenomenon of transposition induction was demonstrated. We estimated rates of induced transposition (approximately 10(-2) events per site, per sperm, per generation versus < 10(-3) in control) and showed dose dependence of the rate on the exposure time of the males to ethanol fumes. Experiments with alcohol treatment at limiting doses must end either in death of the individuals or bursts of genetic variability in their progeny. In terms of genetics of an individual, this may mean loss of vital hereditary basis followed by mass degradation of the progeny of the "hard drinkers." In terms of populations genetics, this mode of MGE transposition induction can rapidly create a burst of novel genetic variation, which, apart of great losses, may generate a number of advantageous individuals, i.e., be significant for population survival in new, stressful environments.