Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia

In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 50; no. 6; p. 679
Main Authors Ma, B, Yi, B D, Xing, B R
Format Journal Article
LanguageChinese
Published China 01.12.1998
Subjects
Animals
B-Lymphocytes - physiology
Excitatory Postsynaptic Potentials - drug effects
Female
Ganglia, Parasympathetic - cytology
Ganglia, Parasympathetic - physiology
Hydrocortisone - analogs & derivatives
Hydrocortisone - pharmacology
In Vitro Techniques
Male
Rana catesbeiana
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Summary:In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc, with a latency less than 3 min after the beginning of perfusion of F-suc. The inhibition of F-suc was concentration-dependent and could be blocked by the antagonist of intracellular glucocorticoid receptor RU38486, but not by the protein synthesis inhibitor actidione. These findings suggest that the inhibition of f-EPSP of B cells by F-suc is probably mediated through a nongenomic mechanism.
ISSN:0371-0874