Successful complete androgen blockade (CAB) therapy for prostatic cancer detected from multiple lung metastases: a case report

• Published in: Hinyokika kiyo. Acta urologica Japonica Vol. 47; no. 1; pp. 59 - 62
• Main Authors: Tokumitsu, M, Inada, F, Kitahara, K, Kawakami, N, Masui, N, Ishida, H, Saga, Y, Hashimoto, H, Yachiku, S
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.01.2001
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - drug therapy; Adenocarcinoma - secondary; Aged; Androgen Antagonists - administration & dosage; Antineoplastic Agents, Hormonal - administration & dosage; Biomarkers, Tumor - blood; Drug Therapy, Combination; Flutamide - administration & dosage; Goserelin - administration & dosage; Humans; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Male; Prostate-Specific Antigen - blood; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Radiography; Treatment Outcome
• ISSN: 0018-1994

Prostatic cancer is rarely diagnosed by detection of lung metastases. We report a case of prostatic cancer in a 73-year-old man detected by abnormalities in chest X-ray and serum prostate specific antigen (PSA) level. He was initially admitted to our hospital due to elevation of PSA level. On the first transperineal prostatic needle biopsy, prostatic cancer was not detected and he was followed. Seven months after the first biopsy, chest X-ray revealed multiple abnormal nodules in the lung fields bilaterally and PSA level was again elevated. A second prostatic biopsy and whole-body examination were performed, and he was diagnosed with moderately differentiated prostatic adenocarcinoma with multiple lung metastases. Complete androgen blockade therapy was performed immediately. Two months after the beginning of treatment, PSA level was normalized and the multiple lung metastases had completely disappeared. There has been no evidence of recurrence or PSA relapse 24 months after detection of the prostatic cancer. This is the 26th case of prostatic cancer diagnosed in Japan following detection of multiple lung metastases.