Detection of eotaxin and its clinical diagnosis value in patients with bronchial asthma

To explore the role of eotaxin in the pathogenesis of bronchial asthma and the clinical value in the diagnosis of asthma. Serum eotaxin were measured by ELISA in 38 patients with asthma, 28 patients with non-asthma allergy, and 30 healthy controls. The levels of serum eotaxin in the asthma group wer...

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Published inZhōngguó yīxué kēxuéyuàn xuébào Vol. 26; no. 3; p. 298
Main Authors Liu, Zhong-juan, Ren, Yan-li, Lin, Jia-you, Ni, An-ping
Format Journal Article
LanguageChinese
Published China 01.06.2004
Subjects
Adult
Asthma - diagnosis
Asthma - physiopathology
Cell Count
Chemokine CCL11
Chemokines, CC - blood
Chemokines, CC - physiology
Eosinophilia - pathology
Female
Forced Expiratory Volume
Humans
Male
Middle Aged
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Summary:To explore the role of eotaxin in the pathogenesis of bronchial asthma and the clinical value in the diagnosis of asthma. Serum eotaxin were measured by ELISA in 38 patients with asthma, 28 patients with non-asthma allergy, and 30 healthy controls. The levels of serum eotaxin in the asthma group were higher than those in the non-asthma allergic and control group (P<0.01). Furthermore, eotaxin levels in patients with acute asthma were significantly higher than those in patients with stable asthma (P<0.001). It was also found that the eotaxin levels of the acute asthma group were positively correlated to the amounts of eosinophils in peripheral blood (r=0.4196, P<0.001), and inversely correlated to the forced expiratory volume in one second (FEV1) (r=-0.3746, P<0.001). It suggests that eotaxin may play a crucial pathogenic role in the asthmatic process possibly by activating the allergic inflammatory cells and controlling the recruitment of eosinophils from blood to bronchial epithelium of the airway. The conce
ISSN:1000-503X