A child with Bartonella henselae osteomyelitis of the right humerus

We present a case of a 22-month-old child with swollen upper part of the right arm and osteolytic lesion of the right humerus, which resembled a neoplastic process. Epidemiological history revealed no scratch marks on the skin or cutaneous papule or pustule. Presumptive diagnosis of hematogenous ost...

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Bibliographic Details
Published inActa dermatovenerologica Croatica Vol. 12; no. 2; p. 92
Main Authors Ledina, Dragan, Rincić, Josko, Ivić, Ivo, Marasović, Dujomir, Ledina, Dubravka
Format Journal Article
LanguageEnglish
Published Croatia 2004
Subjects
Animals
Anti-Bacterial Agents
Bartonella henselae - isolation & purification
Cat-Scratch Disease - diagnosis
Cat-Scratch Disease - drug therapy
Cats
Drug Therapy, Combination - therapeutic use
Female
Humans
Humerus
Infant
Osteomyelitis - diagnosis
Osteomyelitis - drug therapy
Osteomyelitis - microbiology
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Summary:We present a case of a 22-month-old child with swollen upper part of the right arm and osteolytic lesion of the right humerus, which resembled a neoplastic process. Epidemiological history revealed no scratch marks on the skin or cutaneous papule or pustule. Presumptive diagnosis of hematogenous osteomyelitis was established, but treatment with fusidic acid was unsuccessful. Histological examination of the bioptic specimen of the soft tissue swelling showed a lymph node morphology, with numerous granulomas with central stellate necrosis. Indirect immunofluorescence assay for Bartonella henselae yielded positive results. New treatment included 15 days of trimetoprime and sulfamethoxazole, followed by azithromycin for 5 days. Four months later, swelling resolved and osteolytic lesion almost completely healed with formation of surrounding sclerosis. In conclusion, cat-scratch disease without positive epidemiological history and primary cutaneous papule or pustule may be a serious diagnostic problem, but can be solved by serological and histological examination.
ISSN:1330-027X