C5a receptor antagonists for the treatment of inflammation

The anaphylatoxin C5a is a classic, potent inflammatory mediator, with biological activities that have been implicated in a variety of diseases. As a result of two decades of study, C5a receptor antagonists that prevent high-affinity binding of C5a to its receptor have been discovered, which show th...

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Bibliographic Details
Published inCurrent opinion in investigational drugs (London, England : 2000) Vol. 5; no. 5; p. 505
Main Author Sumichika, Hiroshi
Format Journal Article
LanguageEnglish
Published England 01.05.2004
Subjects
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Complement C5a - metabolism
Disease Models, Animal
Drug Design
Humans
Inflammation - drug therapy
Inflammation - metabolism
Receptor, Anaphylatoxin C5a - antagonists & inhibitors
Receptor, Anaphylatoxin C5a - metabolism
Structure-Activity Relationship
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Summary:The anaphylatoxin C5a is a classic, potent inflammatory mediator, with biological activities that have been implicated in a variety of diseases. As a result of two decades of study, C5a receptor antagonists that prevent high-affinity binding of C5a to its receptor have been discovered, which show therapeutic effects in various inflammatory disease models. Moreover, the involvement of C5a in disease models has been demonstrated in various experiments using C5/C5a receptor-deficient mice and anti-C5/C5a antibodies. It is therefore anticipated that these antagonists will have potential as novel anti-inflammatory therapeutics.
ISSN:1472-4472