A synthetic polycation, a copolymer of 1-vinyl-3-methylimidazole iodide with maleic acid diethyl ester, increases passive ionic permeability in erythrocyte membranes modified by fatty acids

The effect of the synthetic polycation VMII-DEMA (a potential antiheparin agent) on the ion transport through erythrocyte membranes was studied using ion-selective electrodes. We found that the passive ionic permeability of erythrocyte membranes in the presence of VMII-DEMA noticeably increased afte...

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Bibliographic Details
Published inMembrane & cell biology Vol. 12; no. 3; p. 401
Main Authors Glazunova, O O, Korepanova, E A, Efimov, V S, Smirnov, A I, Vladimirov YuA
Format Journal Article
LanguageEnglish
Published Switzerland 1998
Subjects
Cations - pharmacology
Cell Membrane Permeability - drug effects
Fatty Acids - blood
Heparin Antagonists - pharmacology
Humans
Imidazoles - pharmacology
Ion Transport - drug effects
Maleates - pharmacology
Polymers
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Summary:The effect of the synthetic polycation VMII-DEMA (a potential antiheparin agent) on the ion transport through erythrocyte membranes was studied using ion-selective electrodes. We found that the passive ionic permeability of erythrocyte membranes in the presence of VMII-DEMA noticeably increased after the pretreatment of erythrocytes with long-chain fatty acids. When used separately, neither polycation nor fatty acids changed the membrane permeability at the same concentrations. The efficiency of the combined action of the polycation and fatty acids correlated with the length of the fatty acid (C9-C18) and the number of double bonds in it. The fatty acids C12:0, C13:0 and C18:2 were the most efficient. We suggest that in pathologies accompanied with deteriorations in lipid metabolism, polycations used for the correction of blood coagulation may damage the erythrocyte membrane.
ISSN:1023-6597