Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels

In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by a...

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Bibliographic Details
Published inNews in physiological sciences Vol. 17; p. 22
Main Authors Bernheim, Laurent, Bader, Charles R
Format Journal Article
LanguageEnglish
Published United States 01.02.2002
Subjects
Calcium Channels - physiology
Cell Differentiation - physiology
Cell Fusion
Electrophysiology
Humans
Muscle, Skeletal - cytology
Muscle, Skeletal - physiology
Potassium Channels, Inwardly Rectifying - physiology
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Summary:In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by alpha 1H T-type Ca(2+) channels), which causes intracellular Ca(2+) to rise.
ISSN:0886-1714
1522-161X
DOI:10.1152/physiologyonline.2002.17.1.22