Subclassification of seronegative type 1 diabetic subjects with HLA-DQ genotypes

To reveal the relationship between disease phenotype and HLA-DQ genotype in autoantibody-negative type 1 diabetics and to explore whether HLA-DQ genotypes can reclassify seronegative type 1 diabetic patients. Sixty-one diabetics with unprovoked ketosis or ketoacidosis at presentation were tested for...

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Published inChung-hua nei kʿo tsa chih Vol. 43; no. 3; p. 174
Main Authors Zhang, Dong-mei, Zhou, Zhi-guang, Zhang, Chi, Huang, Gan, Jin, Ping, Wang, Jian-ping, Wei, Jia-li, Hu, Bai-ying
Format Journal Article
LanguageChinese
Published China 01.03.2004
Subjects
Adolescent
Adult
Aged
Autoantibodies - blood
Child
Diabetes Mellitus, Type 1 - classification
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Female
Genotype
HLA-DQ Antigens - genetics
Humans
Male
Middle Aged
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Summary:To reveal the relationship between disease phenotype and HLA-DQ genotype in autoantibody-negative type 1 diabetics and to explore whether HLA-DQ genotypes can reclassify seronegative type 1 diabetic patients. Sixty-one diabetics with unprovoked ketosis or ketoacidosis at presentation were tested for glutamic acid decarboxylase antibody (GAD-Ab), tyrosine phosphatase antibody (IA2-Ab), thyroglobulin antibody (TGA), thyroid peroxidase antibody (TPO-Ab) and HLA-DQ genotype. GAD-Ab and IA2-Ab were measured with radioligand assay. TGA and TPO-Ab were evaluated using RIA. Sequence-based genotyping (SBT) was used to determine the alleles of HLA-DQA1 and DQB1. Autoantibody negative patients were subdivided into group A (with type 1 diabetes susceptible alleles) and group B (without type 1 diabetes susceptible alleles). Clinical characteristics, including age, sex, mode of presentation, body mass index (BMI), islet beta-cell function and current treatment were compared between the autoantibody-positive and autoantibod
ISSN:0578-1426