The role of phosphatidylserine in recognition and removal of erythrocytes

During the time that erythrocytes (RBC) spend in the circulation, a series of progressive events take place that lead to their removal and determine their apparent aging and limited survival. In addition, a fraction of RBC precursors will be removed during erythropoiesis by apoptotic processes, ofte...

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Published inCellular and molecular biology (Noisy-le-Grand, France) Vol. 50; no. 2; p. 147
Main Authors Kuypers, F A, de Jong, K
Format Journal Article
LanguageEnglish
Published France 01.03.2004
Subjects
Anemia, Sickle Cell - physiopathology
Apoptosis - physiology
Diabetes Mellitus - physiopathology
Erythrocyte Membrane - pathology
Erythrocyte Membrane - physiology
Erythrocytes - pathology
Erythrocytes - physiology
Humans
Macrophages - physiology
Models, Biological
Phosphatidylserines - physiology
Phospholipids - physiology
Spherocytosis, Hereditary - physiopathology
Thalassemia - physiopathology
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Summary:During the time that erythrocytes (RBC) spend in the circulation, a series of progressive events take place that lead to their removal and determine their apparent aging and limited survival. In addition, a fraction of RBC precursors will be removed during erythropoiesis by apoptotic processes, often described as "ineffective erythropoiesis". Both will determine the survival of erythroid cells and play an important role in red cell pathology, including hemoglobinopathies and red cell membrane disorders. The loss of phospholipid asymmetry, and the exposure of phosphatidylserine (PS) on the surface of plasma membranes may be a general trigger by which cells, including aging RBC and apoptotic cells, are removed. Oxidant stress and inactivation of the system that maintains phospholipid asymmetry play a central role in the events that will lead to PS exposure, death and removal.
ISSN:0145-5680