Hypogammaglobulinemia associated with thymoma (Good syndrome) similar to diffuse panbronchiolitis

A 65-year-old woman complained of dyspnea and a productive cough after surgical treatment and irradiation therapy for thymoma. Chest radiography and high-resolution computed tomography showed small nodules in centrilobular lesions in all of both lung fields, but predominantly in the lower fields. In...

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Bibliographic Details
Published inNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society Vol. 41; no. 6; p. 421
Main Authors Tsuburai, Takahiro, Ikehara, Kunihiko, Suzuki, Shunsuke, Shinohara, Takeshi, Mishima, Wataru, Tagawa, Akihiro, Itou, Masaru, Miyazawa, Naoki, Nishiyama, Harumi, Shoji, Akira, Suzuki, Motoyoshi, Matsuse, Takeshi, Ishigatsubo, Yoshiaki
Format Journal Article
LanguageJapanese
Published Japan 01.06.2003
Subjects
Agammaglobulinemia - complications
Aged
Anti-Bacterial Agents - therapeutic use
Bronchiolitis - drug therapy
Bronchiolitis - etiology
Erythromycin - therapeutic use
Female
Humans
Sinusitis - complications
Sinusitis - drug therapy
Syndrome
Thymoma - complications
Thymus Neoplasms - complications
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Summary:A 65-year-old woman complained of dyspnea and a productive cough after surgical treatment and irradiation therapy for thymoma. Chest radiography and high-resolution computed tomography showed small nodules in centrilobular lesions in all of both lung fields, but predominantly in the lower fields. In addition, blood tests showed hypogammaglobulinemia. Chronic sinusitis, mild hypoxemia, severe obstructive impairment and the pathological findings of bronchiolitis led to a diagnosis of sinobronchial syndrome caused by Good syndrome. Treatment with oral erythromycin 600 mg/day was started. After 6 months, the patient improved both clinically and radiologically. Low-dose, long-term treatment with erythromycin was effective against sinobronchial syndrome caused by Good syndrome.
ISSN:1343-3490