Studies on somatostatin mRNA expression in frontal cortex of diabetic rats model

To study the changes of somatostatin (SST) in frontal cortex of the brain of quick streptozotocin-induced diabetes rats. We established the quick-diabetic rats model by injecting streptozotocin intraperitoneally with 60 mg/kg and compared the changes of SST in frontal cortex of diabetic model with n...

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Bibliographic Details
Published inShi yan sheng wu xue bao Vol. 36; no. 3; p. 221
Main Authors Zhang, Xiao Ming, Zhu, Xi, Yuan, Zhang Gen, Ren, Guo Liang, Li, Ji Cheng
Format Journal Article
LanguageChinese
Published China 01.06.2003
Subjects
Animals
Diabetes Mellitus, Experimental - metabolism
Frontal Lobe - metabolism
Image Processing, Computer-Assisted
In Situ Hybridization
Male
Neurons - metabolism
Rats
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Somatostatin - biosynthesis
Somatostatin - genetics
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Summary:To study the changes of somatostatin (SST) in frontal cortex of the brain of quick streptozotocin-induced diabetes rats. We established the quick-diabetic rats model by injecting streptozotocin intraperitoneally with 60 mg/kg and compared the changes of SST in frontal cortex of diabetic model with normal rats by using in situ hybridization and computer image analysis. The number, light density and the average area of positive cells in frontal cortex of diabetic model were reduced significantly in comparison with those of normal rats (P < 0.01). These results indicated that the decline of SST mRNA expression in frontal cortex may relate to chronic diabetes encephalopathy.
ISSN:0001-5334