Somatostatin mRNA expression in hippocampus of diabetic rats model

To investigate the relationship between diabetes and somatostatin (SOM). We established a streptozocin-induced diabetic rats model and studied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis. We studied the mechanism of chr...

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Published inZhōngguó yīxué kēxuéyuàn xuébào Vol. 25; no. 2; p. 204
Main Authors Zhang, Xiao-ming, Zhu, Xi, Yuan, Zhang-gen, Yu, Jun, Zhou, Ji-lin
Format Journal Article
LanguageChinese
Published China 01.04.2003
Subjects
Animals
Brain Diseases - etiology
Brain Diseases - metabolism
Dentate Gyrus - metabolism
Diabetes Mellitus, Experimental - metabolism
Diabetic Neuropathies - metabolism
Hippocampus - metabolism
Male
Rats
Rats, Sprague-Dawley
RNA, Messenger - biosynthesis
Somatostatin - biosynthesis
Somatostatin - genetics
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Summary:To investigate the relationship between diabetes and somatostatin (SOM). We established a streptozocin-induced diabetic rats model and studied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis. We studied the mechanism of chronic diabetes encephalopathy by observing the changes of somatostatin mRNA in the hippocampus of diabetic rats was studied. The number, light density and average area of positive cells in dentate gyrus area of hippocampus in diabetes model were reduced significantly as compared with normal rats (P < 0.01). A decline in SOM mRNA expression may play a role in chronic diabetes encephalopathy because of SOM effect in brain.
ISSN:1000-503X