TGF-beta1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion

We investigated the effect of TGF-beta1 on liver metastasis of pancreatic cancer using surgical specimens of pancreatic cancer and human pancreatic cancer cell lines Capan-2 and SW1990. Immunostaining of TGF-beta1 showed that TGF-beta1 positivity was significantly related to venous invasion and tumo...

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Published inInternational journal of oncology Vol. 19; no. 4; p. 709
Main Authors Teraoka, H, Sawada, T, Yamashita, Y, Nakata, B, Ohira, M, Ishikawa, T, Nishino, H, Hirakawa, K
Format Journal Article
LanguageEnglish
Published Greece 01.10.2001
Subjects
Adenocarcinoma - metabolism
Adenocarcinoma - secondary
Adult
Aged
Aged, 80 and over
Animals
Female
Humans
Immunoenzyme Techniques
Liver Neoplasms - metabolism
Liver Neoplasms - secondary
Male
Matrix Metalloproteinases - metabolism
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Staging
Neoplasm Transplantation
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Pancreaticoduodenectomy
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta - pharmacology
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - metabolism
Urokinase-Type Plasminogen Activator - metabolism
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Summary:We investigated the effect of TGF-beta1 on liver metastasis of pancreatic cancer using surgical specimens of pancreatic cancer and human pancreatic cancer cell lines Capan-2 and SW1990. Immunostaining of TGF-beta1 showed that TGF-beta1 positivity was significantly related to venous invasion and tumor staging, and also relatively associated with liver metastasis. Cellular invasion and protease production of MMP-2 and u-PA, and in vivo liver metastasis were significantly enhanced after treatment of cells with TGF-beta1. These findings suggest that TGF-beta1 might play an important role in enhancing liver metastasis of pancreatic cancer.
ISSN:1019-6439