Clitoria ternatea (Linn) root extract treatment during growth spurt period enhances learning and memory in rats

• Published in: Indian journal of physiology and pharmacology Vol. 45; no. 3; pp. 305 - 313
• Main Authors: Rai, K S, Murthy, K D, Karanth, K S, Rao, M S
• Format: Journal Article
• Language: English
• Published: India 01.07.2001
• Subjects: Animals; Animals, Newborn; Avoidance Learning - drug effects; Behavior, Animal - drug effects; Brain - growth & development; Conditioning, Operant - drug effects; Growth - physiology; India; Learning - drug effects; Maze Learning - drug effects; Medicine, Ayurvedic; Memory - drug effects; Plant Extracts - pharmacology; Plant Roots - chemistry; Plants, Medicinal - chemistry; Rats; Rats, Wistar; India
• ISSN: 0019-5499

Neonatal rat pups (7 days old) were intubated with either 50 mg/kg body weight or 100 mg/kg body weight of aqueous root extract of Clitoria ternatea (CTR) for 30 days. These rats were then subjected to open field, two compartment passive avoidance and spatial learning (T-Maze) tests (i) immediately after the treatment and (ii) 30 days after the treatment, along with age matched normal and saline control rats. Results showed no change in open field behaviour, but showed improved retention and spatial learning performance at both time points of behavioural tests, indicating the memory enhancing property of CTR which implicates a permanent change in the brain of CTR treated rats.