Invasive bladder cancer after cyclophosphamide administration for nephrotic syndrome--a case report

We report a case of invasive bladder cancer after cyclophosphamide administration for nephrotic syndrome, and briefly discuss the association of bladder cancer and cyclophosphamide. A 6-year-old boy, who was diagnosed as having nephrotic syndrome, was treated with oral administration of prednisolone...

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Bibliographic Details
Published inHiroshima journal of medical sciences Vol. 49; no. 2; p. 121
Main Authors Nakamoto, T, Kasaoka, Y, Ikegami, Y, Usui, T
Format Journal Article
LanguageEnglish
Published Japan 01.06.2000
Subjects
Adult
Antineoplastic Agents, Alkylating - adverse effects
Carcinoma, Transitional Cell - chemically induced
Carcinoma, Transitional Cell - diagnosis
Cyclophosphamide - adverse effects
Humans
Male
Nephrotic Syndrome - drug therapy
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - diagnosis
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Summary:We report a case of invasive bladder cancer after cyclophosphamide administration for nephrotic syndrome, and briefly discuss the association of bladder cancer and cyclophosphamide. A 6-year-old boy, who was diagnosed as having nephrotic syndrome, was treated with oral administration of prednisolone and cyclophosphamide for 4 years, receiving a total dose of 49.5 g cyclophosphamide. At age 27, a gross hematuria with bloody clots appeared and he presented with postrenal renal failure. He underwent a radical cystourethrectomy and ileal conduit for stage a pT3a pN0 M0 transitional cell carcinoma of the bladder. He was not given any adjuvant treatments because of his renal insufficiency, and he died from the disease 14 months after radical surgery.
ISSN:0018-2052