Involvement of peripheral 5-HT2A receptor activation in inflammatory pain

Serotoninergic neuron is concerned as an one of the pivotal factor of the tissue inflammation which lead to pain behavior. Sarpogrelate HCl is a novel compound which may modulate inflammatory reaction through 5-HT2A receptor antagonist. We show the involvement of the 5-HT2A receptor activity in the...

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Bibliographic Details
Published inNihon rinshō Vol. 59; no. 9; p. 1675
Main Authors Nakanishi, O, Ishikawa, T
Format Journal Article
LanguageJapanese
Published Japan 01.09.2001
Subjects
Animals
Humans
Neuralgia - drug therapy
Neuralgia - etiology
Neurogenic Inflammation - drug therapy
Neurogenic Inflammation - etiology
Receptor, Serotonin, 5-HT2A
Receptors, Serotonin - metabolism
Serotonin Antagonists - pharmacology
Serotonin Antagonists - therapeutic use
Succinates - pharmacology
Succinates - therapeutic use
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Summary:Serotoninergic neuron is concerned as an one of the pivotal factor of the tissue inflammation which lead to pain behavior. Sarpogrelate HCl is a novel compound which may modulate inflammatory reaction through 5-HT2A receptor antagonist. We show the involvement of the 5-HT2A receptor activity in the inflammatory and neuropathic pain. Systemic or local sarpogrelate administration provokes antinociceptive effect on 5-HT- or formalin-produced inflammatory pain behaviour in relation to spinal glutamate. Local sarpogrelate inhibits apoptosis and neuronal degeneration after chronic construction injury(CCI). These effects are reversed by 5-HT2A receptor agonist. These results suggests sarpogrelate has a beneficial effect on hyperalgesia and neuropathic pain via inhibiting 5-HT2A receptor.
ISSN:0047-1852