Intra-operative radionuclide lymphatic mapping in sentinel lymph node biopsy of breast cancer

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 25; no. 6; p. 604
• Main Authors: Lou, Cen, Huang, Zhong-ke, Song, Xiang-yang, Zhang, Da-ping, Huang, Hua-cheng
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2003
• Subjects: Adult; Aged; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Female; Humans; Lymph Nodes - diagnostic imaging; Middle Aged; Radionuclide Imaging; Sentinel Lymph Node Biopsy; Technetium Tc 99m Sulfur Colloid
• ISSN: 0253-3766

To study intra-operative radionuclide lymphatic mapping in sentinel lymph node (SLN) biopsy of breast cancer. Forty-two breast cancer (diameter </= 5.0 cm) patients with clinically negative axillary node were analyzed. 18.5 MBq/0.5 ml technetium-99m labeled sulfur colloid (labeling yield > 98%, size of colloid granule 100 approximately 200 nm) was injected into the mammary tissue around the tumor or biopsy site at four points. SLN in breast cancer was detected and dissected with the help of lymphoscintigraphy and intra-operative gamma probe. Routine lymph node dissection was performed for all patients. The detection rate was 88.1% in lymphoscintigraphy and 97.6% in intra-operative gamma probe detection for SLN in breast cancer. The sensitivity, accuracy, false negative and specificity of SLN biopsy were 93.3% (14 in 15), 97.6% (40 in 41), 6.7% (1 in 15) and 100% (26 in 26). Sentinel lymph node in breast cancer, detected by preoperative lymphoscintigraphy combined with intra-operative gamma probe, is able to p