Establishment and characterization of cell lines derived from serous adenocarcinoma (JHOS-2) and clear cell adenocarcinoma (JHOC-5, JHOC-6) of human ovary

The cell lines designated JHOS-2, JHOC-5 and JHOC-6 were established from epithelial ovarian carcinomas. JHOS-2 was established from a serous adenocarcinoma of a 45-year-old Japanese woman, JHOC-5 from a recurrent tumor of a clear cell adenocarcinoma of a 47-year-old Japanese woman and JHOC-6 from a...

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Published inHuman cell : official journal of Human Cell Research Society Vol. 12; no. 3; p. 131
Main Authors Yamada, K, Tachibana, T, Hashimoto, H, Suzuki, K, Yanagida, S, Endoh, H, Kimura, E, Yasuda, M, Tanaka, T, Ishikawa, H
Format Journal Article
LanguageEnglish
Published Japan 01.09.1999
Subjects
Adenocarcinoma, Clear Cell - pathology
Adenocarcinoma, Clear Cell - ultrastructure
Adult
Animals
Biomarkers, Tumor - analysis
CA-125 Antigen - analysis
Cystadenocarcinoma, Serous - pathology
Cystadenocarcinoma, Serous - ultrastructure
Female
Humans
Karyotyping
Mice
Microscopy, Electron
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Transplantation
Ovarian Neoplasms - pathology
Ovarian Neoplasms - ultrastructure
Tumor Cells, Cultured
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Summary:The cell lines designated JHOS-2, JHOC-5 and JHOC-6 were established from epithelial ovarian carcinomas. JHOS-2 was established from a serous adenocarcinoma of a 45-year-old Japanese woman, JHOC-5 from a recurrent tumor of a clear cell adenocarcinoma of a 47-year-old Japanese woman and JHOC-6 from a tumor of a clear cell adenocarcinoma of a 43-year-old Japanese woman. These cell lines have grown well and serial passages were successively carried out more than 20 times. The monolayer cultured cells revealed neoplastic and pleomorphic features, and grew in multilayers. Electron micrographs revealed epithelial origins that had desmosomes and tonofilaments.
ISSN:0914-7470
1749-0774