The relationship between bone mineral density and secondary hyperparathyroidism bone disease

The bone mineral density (BMD) and Z score in distal 1/3 radius were measured with dual energy X-ray absorptiometry (DEXA) in 185 hemodialysis (HD) patients, meanwhile serum parathyroid hormone (PTH), alkaline phosphatase (ALP) and hand X-rays were detected. Results showed that BMD in HD patients wa...

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Bibliographic Details
Published inHunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Vol. 25; no. 1; p. 77
Main Authors Ning, J P, Sun, M, Toru, I, Etsuo, Y
Format Journal Article
LanguageChinese
Published China 28.02.2000
Subjects
Absorptiometry, Photon
Adult
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Bone Density
Female
Humans
Hyperparathyroidism, Secondary - physiopathology
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Middle Aged
Osteoporosis - physiopathology
Parathyroid Hormone - blood
Renal Dialysis
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Summary:The bone mineral density (BMD) and Z score in distal 1/3 radius were measured with dual energy X-ray absorptiometry (DEXA) in 185 hemodialysis (HD) patients, meanwhile serum parathyroid hormone (PTH), alkaline phosphatase (ALP) and hand X-rays were detected. Results showed that BMD in HD patients was significantly lower than that in control group(P < 0.05), and decreased with dialysis duration increasing. BMD in HD patients was negatively related with PTH, ALP and rate of subperiosteal erosions. By using Z score to diagnose hyperparathyroidism bone disease, receiver operating characteristic (ROC) curve was worked out. If Z score < or = -2.02, the sensitivity was 79.41% and specificity was 78.15%. In conclusion the measurement of BMD is a useful tool for the detection of hyperparathyroid bone disease.
ISSN:1000-5625