Isolation and elucidation of chemical constituents of shandanshaoyao decoction (II)

• Published in: Zhongguo zhongyao zazhi Vol. 26; no. 7; p. 474
• Main Authors: Wen, Z M, Xu, L X
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2001
• Subjects: Apigenin; Benzoates - chemistry; Benzoates - isolation & purification; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - isolation & purification; Crataegus - chemistry; Drug Combinations; Flavonoids - chemistry; Flavonoids - isolation & purification; Glucosides - chemistry; Glucosides - isolation & purification; Monoterpenes; Paeonia - chemistry; Plants, Medicinal - chemistry; Quercetin - analogs & derivatives; Quercetin - chemistry; Quercetin - isolation & purification; Salvia miltiorrhiza - chemistry
• ISSN: 1001-5302

To study the chemical constituents of Shandanshaoyao Decoction. The sample was prepared by boiling water, then precipitated by 75% of ethanol. The ethanol soluble fraction was extracted by chloroform, ethyl acetate and n-butanol, respectively. The extracts were isolated using macroreticular resin, silica gel and polyamide column chromatography, and then the chemical constituents were identified by chemical and spectroscopic methods. Nine compounds were isolated from the n-butanol extract and water soluble fraction, and elucidated as vitexin, quercetin, hyperoside, rutin, paeoniflorin, protocatechaldehyde, (+)-catechin, danshensu and citric acid respectively. The chemical constituents of traditional Chinese medicinal preparations Shandanshaoyao Decoction were reported for the first time.