Prognostic factors influencing survival in patients with large hepatocellular carcinoma receiving combined transcatheter arterial chemoembolization and radiotherapy

• Published in: Zhonghua gan zang bing za zhi Vol. 10; no. 3; p. 167
• Main Authors: Guo, Weijian, Yu, Erxin, Yi, Chen, Wu, Wanyin, Lin, Junhua
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2002
• Subjects: Adult; Aged; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - radiotherapy; Carcinoma, Hepatocellular - therapy; Embolization, Therapeutic; Female; Humans; Liver Neoplasms - diagnosis; Liver Neoplasms - mortality; Liver Neoplasms - radiotherapy; Liver Neoplasms - therapy; Male; Middle Aged; Prognosis; Survival Rate
• ISSN: 1007-3418

To observe the long-term effects of combined transcatheter arterial chemoembolization (TACE) and radiotherapy for patients with large hepatocellular carcinoma (HCC) and to analyze the prognostic factors. A total of 107 patients with large unresectable HCC (the largest diameter of tumor ranged from 5 to 18 cm) were treated with TACE followed by external-beam irradiation. Acute effects and survival rates were observed. The Cox proportional hazards model was used to analyze the prognostic factors. An objective response was achieved in 48.6% of the cases. The cumulative survival rates at 1, 3, and 5 years were 59.4%, 28.4%, and 15.8%, respectively. The tumor number and irradiation dose were the independent prognostic factors. The cumulative survival rates of the patients with a solitary lesion (75.8%, 43.9%, and 26.8% at 1, 3, and 5 years, respectively) were significantly higher than those with multiple lesions (31.3%, and 5.0% at 1 and 3 years, respectively, P=0.0005). The survival rates of the patients received