Breast cancer with osteoblastic bone metastasis treated successfully with bisphosphonate: a case report

A 52-year-old woman with painful osteoblastic bone metastasis received pamidronate therapy which resulted in marked pain relief with a normalization of elevated tumor marker levels. However, the patient complained of increased pain after the 26th pamidronate infusion. Although a change from pamidron...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 26; no. 11; p. 1651
Main Authors Oura, S, Sakurai, T, Yoshimura, G, Tamaki, T, Umemura, T, Kokawa, Y
Format Journal Article
LanguageJapanese
Published Japan 01.10.1999
Subjects
Analgesics - administration & dosage
Bone Neoplasms - drug therapy
Bone Neoplasms - secondary
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - drug therapy
Carcinoma, Ductal, Breast - secondary
Diphosphonates - administration & dosage
Drug Administration Schedule
Female
Humans
Middle Aged
Pain, Intractable - drug therapy
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Summary:A 52-year-old woman with painful osteoblastic bone metastasis received pamidronate therapy which resulted in marked pain relief with a normalization of elevated tumor marker levels. However, the patient complained of increased pain after the 26th pamidronate infusion. Although a change from pamidronate to alendronate therapy did not relieve bone pain, a second change from alendronate to incadronate therapy resulted in pain relief with a decrease in re-elevated tumor marker levels. These findings suggest that bisphosphonate therapy is effective against osteoblastic bone metastasis in breast cancer, and that sequential therapy with bisphosphonates may be effective against bone metastasis in some cases.
ISSN:0385-0684