Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta
A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrab...
Saved in:
Published in | The Journal of nuclear medicine (1978) Vol. 27; no. 5; pp. 714 - 721 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.05.1986
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrabutylammonium fluoride, SN2 displacement of a triflate, and ketone reduction) and is purified by high performance liquid chromatography (HPLC). All steps in the synthesis and HPLC purification are controlled by the robot system with no manual intervention. This represents a new approach to the complete automation of radiopharmaceutical production. |
---|---|
AbstractList | A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrabutylammonium fluoride, SN2 displacement of a triflate, and ketone reduction) and is purified by high performance liquid chromatography (HPLC). All steps in the synthesis and HPLC purification are controlled by the robot system with no manual intervention. This represents a new approach to the complete automation of radiopharmaceutical production. |
Author | Kilbourn, M R Welch, M J Brodack, J W Katzenellenbogen, J A |
Author_xml | – sequence: 1 givenname: J W surname: Brodack fullname: Brodack, J W – sequence: 2 givenname: M R surname: Kilbourn fullname: Kilbourn, M R – sequence: 3 givenname: M J surname: Welch fullname: Welch, M J – sequence: 4 givenname: J A surname: Katzenellenbogen fullname: Katzenellenbogen, J A |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3486960$$D View this record in MEDLINE/PubMed |
BookMark | eNotkDtrwzAYRTWkpGnan1DQ1M0g2dbD3ULoCwJd2tlI1ieiIluqJA_Z-tPrppkuXA6Hy71BqylMsEIbQjmtGCPsGt3k_EUI4VLKNVo3reQdJxv0s4vRu0EVFyYcLE5Bh-KGjEvASRkX4lGlUQ0wL63yOCaIKp3xRzyEqaTgPRicT1M5Qnb5T2L9HJKboKISU46VXyTVuQyQy1nrKyqwhqJu0ZVVPsPdJbfo8_npY_9aHd5f3va7QxVpTUtljWSUCV0bSaBmoDvGODVEkI6Ztq2NtkBEo6mpWatqPQwWuGgtaCY6Jm2zRQ__3pjC97zM6EeXB_BeTRDm3AsuWSs6uoD3F3DWI5g-JjeqdOovlzW_FpVrOg |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM 7X8 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry |
EndPage | 721 |
ExternalDocumentID | 3486960 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, U.S. Gov't, P.H.S Journal Article |
GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: HL13851 |
GroupedDBID | --- -~X .55 .GJ 29L 2WC 3O- 3V. 41~ 53G 5RE 7RV 7X7 88E 88I 8AF 8AO 8FE 8FG 8FH 8FI 8FJ 8R4 8R5 8WZ A6W ABEFU ABSQV ABUWG ACGOD ACIWK ACPRK ADDZX AENEX AFFNX AFKRA AFOSN AFRAH AHMBA AI. ALIPV ALMA_UNASSIGNED_HOLDINGS ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI CCPQU CGR CS3 CUY CVF DIK DU5 DWQXO E3Z EBD EBS ECM EIF EJD EMOBN EX3 F5P F9R FYUFA GNUQQ H13 HCIFZ HMCUK I-F I4R IL9 INIJC J5H KQ8 L7B LK8 M1P M2P M2Q M7P N4W NAPCQ NPM OK1 P2P P62 PQQKQ PROAC PSQYO Q2X R0Z RHF RHI RNS RWL S0X SJN SV3 TAE TR2 TSM TUS UKHRP VH1 W8F WH7 WOQ WOW X7M YHG YQJ ZGI ZXP 7X8 |
ID | FETCH-LOGICAL-p121t-fd85157b2d80e25eb95561d07095d442dbfe073b1d254a2bccfe674feb57958f3 |
ISSN | 0161-5505 |
IngestDate | Sat Aug 17 03:26:00 EDT 2024 Sat Sep 28 07:31:48 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p121t-fd85157b2d80e25eb95561d07095d442dbfe073b1d254a2bccfe674feb57958f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 3486960 |
PQID | 76854791 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | proquest_miscellaneous_76854791 pubmed_primary_3486960 |
PublicationCentury | 1900 |
PublicationDate | 1986-May 19860501 |
PublicationDateYYYYMMDD | 1986-05-01 |
PublicationDate_xml | – month: 05 year: 1986 text: 1986-May |
PublicationDecade | 1980 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of nuclear medicine (1978) |
PublicationTitleAlternate | J Nucl Med |
PublicationYear | 1986 |
SSID | ssj0006888 |
Score | 1.4632546 |
Snippet | A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting... |
SourceID | proquest pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 714 |
SubjectTerms | Automation - instrumentation Chemical Phenomena Chemistry Estradiol - analogs & derivatives Estradiol - chemical synthesis Fluorine Isotope Labeling Radioisotopes Tomography, Emission-Computed |
Title | Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta |
URI | https://www.ncbi.nlm.nih.gov/pubmed/3486960 https://search.proquest.com/docview/76854791 |
Volume | 27 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoJaCXCgoV5ekDt5XROrEdh1tbWpWullMrelvFj9BKIYm22QM98dMZPzYJqCsBl2jlRNZqvk_j8TwReg9GcsryqSasEIwwbiSRyk6JLLiL4_CSaVcoPP8izi7Z-RW_GkIxvrqkUx_03b11Jf-DKqwBrq5K9h-Q7TeFBfgN-MITEIbnX2F8OESfndG3bFTjuy6DPbkszE3TXv_msG6XNnT6DukcMUu9ApPz9kcNhmDsTVJWK5eVZwmVEyomvhqX-MXGOscIbFwRmrkUr2Js2w5VZlVID9FuJEUfvfctoeA2OfI9HIH2LoI-Pp_0zp7ZTeVdrd5XOyQ0frVVGFs1H0JZs6K7sy5Rx9aq-RbrTKJ71oTaPimGxMG1d1NQ4q5MY_UcWgdEGvKRrs1C9ekI5_a7BzplUuRhSsEfvbTjmy20lVKX__np86w_toX0Q0r7_7CDHsbPN18-vBFy8QTtRuniw0CFp-iBrffQ4-P10L499Ggepf0M_RyxAzclXrMDdw2-hx14xI6PeOAG7rnhNhlxA1OBN3EDO248R5enJxfHZyTO2yAtTWhHSgPmN89UYuTUJtyq3M1ONXAo5NwwlhhVWjgRFDUJZ0WitC6tyFhpFc9yLst0H23XTW1fICxTY2AxtzoTbJpauByBtqBpUmqjjVAH6N1apAuQkAtSFbVtVrcLuP5yluX0AO0HSS_a0HZlEdF4uenFK7QzkOo12u6WK_sGLMZOvfVI_wI5THKr |
link.rule.ids | 315,786,790 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Application+of+robotics+to+radiopharmaceutical+preparation%3A+controlled+synthesis+of+fluorine-18+16+alpha-fluoroestradiol-17+beta&rft.jtitle=The+Journal+of+nuclear+medicine+%281978%29&rft.au=Brodack%2C+J+W&rft.au=Kilbourn%2C+M+R&rft.au=Welch%2C+M+J&rft.au=Katzenellenbogen%2C+J+A&rft.date=1986-05-01&rft.issn=0161-5505&rft.volume=27&rft.issue=5&rft.spage=714&rft_id=info%3Apmid%2F3486960&rft.externalDocID=3486960 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0161-5505&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0161-5505&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0161-5505&client=summon |