Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta

A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrab...

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Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 27; no. 5; pp. 714 - 721
Main Authors Brodack, J W, Kilbourn, M R, Welch, M J, Katzenellenbogen, J A
Format Journal Article
LanguageEnglish
Published United States 01.05.1986
Subjects
Automation - instrumentation
Chemical Phenomena
Chemistry
Estradiol - analogs & derivatives
Estradiol - chemical synthesis
Fluorine
Isotope Labeling
Radioisotopes
Tomography, Emission-Computed
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Summary:A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrabutylammonium fluoride, SN2 displacement of a triflate, and ketone reduction) and is purified by high performance liquid chromatography (HPLC). All steps in the synthesis and HPLC purification are controlled by the robot system with no manual intervention. This represents a new approach to the complete automation of radiopharmaceutical production.
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ISSN:0161-5505