The effect of acute and chronic treatment of verapamil on pressor response to angiotensin II in rats

The effect of verapamil on pressor response to Angiotensin II (A II) was investigated in rats. The responses to A II (10, 20, 40 ng, iv) was reduced after verapamil (50 and 100 micrograms, iv per rat) in a dose dependent manner. Treatment for 5 day with verapamil (18 mg/100 g/day, po) let to some re...

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Bibliographic Details
Published inIndian journal of physiology and pharmacology Vol. 30; no. 2; p. 145
Main Authors Lall, S B, Kheterpal, K, Rajdev, S, Gupta, Y K
Format Journal Article
LanguageEnglish
Published India 01.04.1986
Subjects
Angiotensin II - pharmacology
Animals
Blood Pressure - drug effects
Drug Interactions
Male
Rats
Rats, Inbred Strains
Time Factors
Verapamil - administration & dosage
Verapamil - pharmacology
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Summary:The effect of verapamil on pressor response to Angiotensin II (A II) was investigated in rats. The responses to A II (10, 20, 40 ng, iv) was reduced after verapamil (50 and 100 micrograms, iv per rat) in a dose dependent manner. Treatment for 5 day with verapamil (18 mg/100 g/day, po) let to some reduction in basal blood pressure but pressor response to A II was not changed. Treatment for 20 days significantly reduced the basal blood pressure and increased the responsiveness to A II. it is concluded that Ca++ plays a major role in the pressor responses to A II and that chronic treatment with verapamil may reduce basal blood pressure.
ISSN:0019-5499