Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice

Petroleum ether extract from H. spinosa root exhibited antitumor activity in Ehrlich ascites carcinoma and Sarcoma-180 bearing mice Processed extract suppressed significantly the tumor fluid volume at the end of 3 weeks experiment. It decreased about 50% of packed cell volume and increased life span...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 35; no. 5; p. 473
Main Authors Mazumdar, U K, Gupta, M, Maiti, S, Mukherjee, D
Format Journal Article
LanguageEnglish
Published India 01.05.1997
Subjects
Animals
Antineoplastic Agents, Phytogenic - pharmacology
Carcinoma, Ehrlich Tumor - drug therapy
Mice
Plants, Medicinal
Sarcoma 180 - drug therapy
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Summary:Petroleum ether extract from H. spinosa root exhibited antitumor activity in Ehrlich ascites carcinoma and Sarcoma-180 bearing mice Processed extract suppressed significantly the tumor fluid volume at the end of 3 weeks experiment. It decreased about 50% of packed cell volume and increased life span of EAC/S-180 bearing mice in a day dependent manner. Red blood cell count, hemoglobin content and white blood cell count were more or less normal after processed extract treatment of the tumor bearing mice. In tumor control animals, neutrophils increased (273.7% in EAC and 263.4% in S-180 bearing mice respectively with respect to normal mice) whereas lymphocytes decreased (60.0% in EAC and 56.5% in S-180 bearing mice respectively with respect to normal mice). It also inhibited the rapid increase of body weight of tumor bearing mice.
ISSN:0019-5189