Synthesis and antibacterial action of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroylthiocarbamoyl-1-piperaziny l)-3-quinoline carboxylic acids

Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl-1-piperazinyl)-3- quinoline carboxylic acids were prepared. Their structures were characterized by elemental analysis, IR, HNMR and MS spectra. Preliminary pharmacological tests indicated that some of compounds Ia-m possess str...

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Bibliographic Details
Published inYao hsüeh hsüeh pao Vol. 28; no. 6; p. 477
Main Authors Jia, X S, Wang, Y L, He, F S, Shan, Y F, Li, Y F, Wang, Y
Format Journal Article
LanguageChinese
Published China 1993
Subjects
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Bacillus subtilis - drug effects
Escherichia coli - drug effects
Fluoroquinolones
Microbial Sensitivity Tests
Molecular Structure
Piperazines - chemical synthesis
Piperazines - pharmacology
Proteus - drug effects
Quinolones - chemical synthesis
Quinolones - pharmacology
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Summary:Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl-1-piperazinyl)-3- quinoline carboxylic acids were prepared. Their structures were characterized by elemental analysis, IR, HNMR and MS spectra. Preliminary pharmacological tests indicated that some of compounds Ia-m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 micrograms/ml.
ISSN:0513-4870