Effect of capsaicin on the release of substance P from spinal cord and blood pressure

• Published in: Sheng li hsüeh pao Vol. 42; no. 5; p. 446
• Main Authors: Liu, Y, Chen, J A, Han, J D, Xu, Y X, Luo, L, Xu, C T, Zhang, Y P
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.1990
• Subjects: Animals; Blood Pressure - drug effects; Capsaicin - pharmacology; Epinephrine - blood; Female; Ganglia, Autonomic - physiology; Heart Rate - drug effects; Injections, Spinal; Male; Neurons - physiology; Norepinephrine - blood; Rats; Rats, Inbred Strains; Spinal Cord - metabolism; Substance P - metabolism; Substance P - physiology

The role of substance P (SP) in the regulation of sympathetic outflow to the cardiovascular system was assessed. Intrathecal injection(ith) of capsaicin caused a release of SP from the spinal cord and resulted in an increase in blood pressure and heart rate accompanied by an elevation of plasma adre...