Effect of capsaicin on the release of substance P from spinal cord and blood pressure

The role of substance P (SP) in the regulation of sympathetic outflow to the cardiovascular system was assessed. Intrathecal injection(ith) of capsaicin caused a release of SP from the spinal cord and resulted in an increase in blood pressure and heart rate accompanied by an elevation of plasma adre...

Full description

Saved in:
Bibliographic Details
Published inSheng li hsüeh pao Vol. 42; no. 5; p. 446
Main Authors Liu, Y, Chen, J A, Han, J D, Xu, Y X, Luo, L, Xu, C T, Zhang, Y P
Format Journal Article
LanguageChinese
Published China 01.10.1990
Subjects
Animals
Blood Pressure - drug effects
Capsaicin - pharmacology
Epinephrine - blood
Female
Ganglia, Autonomic - physiology
Heart Rate - drug effects
Injections, Spinal
Male
Neurons - physiology
Norepinephrine - blood
Rats
Rats, Inbred Strains
Spinal Cord - metabolism
Substance P - metabolism
Substance P - physiology
Online AccessGet more information

Cover

More Information
Summary:The role of substance P (SP) in the regulation of sympathetic outflow to the cardiovascular system was assessed. Intrathecal injection(ith) of capsaicin caused a release of SP from the spinal cord and resulted in an increase in blood pressure and heart rate accompanied by an elevation of plasma adrenaline and noradrenaline. This pressor response was blocked by ith SP antagonist D-Pro2, D-Phe7, D-Trp9-SP or antiserum against SP. The immunohistochemical study showed that the SP-like immunoreactivity in T-8 of the spinal cord was decreased as the amount of capsaicin administrated was increased. Spinal cord transection had no effect on pressor responses caused by ith 10 micrograms capsaicin. These results suggest that SP transmits excitatory information to the cardiovascular system via spinal sympathetic pathway.
ISSN:0371-0874