A single bolus dose of vecuronium for rapid endotracheal intubation

The changes in EMG evoked by train-of-four (TOF) stimulation of ulnar nerve were recorded to determine proper single bolus dose of vecuronium for endotracheal intubation in surgical patients. Onset and duration of neuromuscular block were judged by percent depression of EMG. Mean time intervals for...

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Bibliographic Details
Published inMasui. The Japanese journal of anesthesiology Vol. 41; no. 1; p. 15
Main Authors Yamada, T, Takino, Y
Format Journal Article
LanguageJapanese
Published Japan 01.01.1992
Subjects
Adult
Humans
Infusions, Intravenous
Intubation, Intratracheal
Middle Aged
Neuromuscular Junction - drug effects
Time Factors
Vecuronium Bromide - administration & dosage
Vecuronium Bromide - pharmacology
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Summary:The changes in EMG evoked by train-of-four (TOF) stimulation of ulnar nerve were recorded to determine proper single bolus dose of vecuronium for endotracheal intubation in surgical patients. Onset and duration of neuromuscular block were judged by percent depression of EMG. Mean time intervals for 90% depression in TOF seen in 0.10 mg.kg-1 vecuronium group (n = 10), 0.15 mg.kg-1 vecuronium group (n = 10) and 0.20 mg.kg-1 vecuronium group (n = 10), were 181.1 sec, 135.0 sec and 120.0 sec, respectively. Similarly, mean time intervals for 100% depression for each vecuronium group were 240.0 sec, 177.5 sec and 160.0 sec, respectively. Onset time intervals in both 0.15 mg.kg-1 and 0.20 mg.kg-1 groups were significantly shorter than that in 0.10 mg.kg-1 group (P less than 0.05). On the other hand, mean time intervals for 25% recovery in EMG were 53.6 min in 0.10 mg.kg-1 group, 63.3 min in 0.15 mg.kg-1 group and 104.3 min in 0.20 mg.kg-1 group. No statistically significant difference was observed in recovery time between 0.10 mg.kg-1 and 0.15 mg.kg-1 group. These results indicate that the appropriate dose of vecuronium for rapid intubation is considered to be 0.15 mg.kg-1. This dose is allowable for surgical procedures of short duration.
ISSN:0021-4892