Clinical studies using measurement of N-telopeptides of type 1 collagen (NTx) in patients with bone metastasis--comparison with bone scintigraphy and other metabolic bone markers

Urinary metabolites of N-telopeptide of type 1 collagen cross-links (NTx) are known as a bone resorption marker. We performed a multi-center trial of NTx measurement in evaluation of bone metastasis. In total, 251 patients with or without bone metastasis from various malignancies were studied. Compa...

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Bibliographic Details
Published inKaku igaku Vol. 32; no. 5; p. 501
Main Authors Yamamoto, I, Morita, R, Konishi, J, Shigeno, C, Ikekubo, K, Hino, M, Sone, T, Fujimoto, R
Format Journal Article
LanguageJapanese
Published Japan 01.05.1995
Subjects
Adult
Aged
Aged, 80 and over
Amino Acids - urine
Biomarkers - urine
Biomarkers, Tumor - blood
Bone and Bones - diagnostic imaging
Bone Neoplasms - blood
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Bone Resorption
Collagen - blood
Collagen Type I
Female
Humans
Male
Middle Aged
Osteocalcin - urine
Peptides - blood
Radionuclide Imaging
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Summary:Urinary metabolites of N-telopeptide of type 1 collagen cross-links (NTx) are known as a bone resorption marker. We performed a multi-center trial of NTx measurement in evaluation of bone metastasis. In total, 251 patients with or without bone metastasis from various malignancies were studied. Comparing with other bone markers such as urinary total deoxypyridinoline, osteocalcin, and bone specific alkaline phosphatase, NTx was the most sensitive one to detect bone metastasis and its levels correlated well with the extensiveness of bone metastasis. Measurement of NTx will be useful to determine to order bone scan in patients with malignancy and to monitor the clinical course in patients with bone metastasis.
ISSN:0022-7854