Influence of hormone replacement therapy (17 beta-OH estradiol and medroxyprogesterone acetate) on plasma concentration of prothrombin fragment F1+2 and thrombin-antithrombin III complex in postmenopausal woman

The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma levels of prothrombin fragment F1+2 and thrombin-antithrombin III complex before the treatment and after 6 and 12 months of HRT in 116 postmenopausal women HRT considere...

Full description

Saved in:
Bibliographic Details
Published inActa haematologica polonica Vol. 27; no. 1; p. 21
Main Authors Ciepłluch, R, Czestochowska, E
Format Journal Article
LanguageEnglish
Published Poland 1996
Subjects
Adult
Aged
Antithrombin III - analysis
Biomarkers - analysis
Estradiol - pharmacology
Estradiol - therapeutic use
Estrogen Replacement Therapy
Female
Humans
Medroxyprogesterone Acetate - pharmacology
Medroxyprogesterone Acetate - therapeutic use
Middle Aged
Peptide Fragments - analysis
Peptide Hydrolases - analysis
Postmenopause - drug effects
Postmenopause - metabolism
Prospective Studies
Prothrombin - analysis
Online AccessGet more information

Cover

More Information
Summary:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma levels of prothrombin fragment F1+2 and thrombin-antithrombin III complex before the treatment and after 6 and 12 months of HRT in 116 postmenopausal women HRT considered of transdermal estradiol and oral medroxyprogesterone acetate. We observed no statistically significant differences in plasma levels of the above coagulation markers before and during the treatment.
ISSN:0001-5814