The selectivity of amino acid and peptide amidination with O-methylisourea

Selectivity of amidination using ornithine as model amino acid was investigated in detail. The results obtained were taken advantage of for studying the reactions with other polyfunctional amino acids: beta-tyrosine, isoserine, 2,3-diaminopropionic acid, 2,6-diamino-7-hydroxyazelaic acid and with th...

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Bibliographic Details
Published inActa biochimica polonica Vol. 29; no. 3-4; pp. 197 - 204
Main Authors Wojciechowska, H, Zgoda, W, Borowski, E
Format Journal Article
LanguageEnglish
Published Poland 1982
Subjects
Amides - chemical synthesis
Amino Acids
Arginine - analogs & derivatives
Chemical Phenomena
Chemistry
Edeine - analogs & derivatives
Hydrogen-Ion Concentration
Methylurea Compounds
Ornithine - analogs & derivatives
Peptides
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Summary:Selectivity of amidination using ornithine as model amino acid was investigated in detail. The results obtained were taken advantage of for studying the reactions with other polyfunctional amino acids: beta-tyrosine, isoserine, 2,3-diaminopropionic acid, 2,6-diamino-7-hydroxyazelaic acid and with the pentapeptide amide, edeine A. It was found that, if the appropriate conditions are maintained, selective amidination of more basic amino groups of polyamino compounds is possible when these groups are bound to the primary alkyl.
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ISSN:0001-527X