Effect of lesions to the supramammillary area of the posterior hypothalamus on atrial natriuretic peptide release following acute blood volume expansion in conscious Wistar rats

Acute blood volume expansion (AVE) is a potent stimulus for atrial natriuretic peptide (ANP) release. Since several central nervous structures are well known for their involvement in the regulation of fluid and electrolyte homeostasis and in the secretion of central ANP, we carried our experiments o...

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Bibliographic Details
Published inActa physiologica et pharmacologica Bulgarica Vol. 21; no. 3; p. 63
Main Authors Belova, N, Kirkova, L, Avramova, T, Piryova, B, Natcheff, N, Thurau, K
Format Journal Article
LanguageEnglish
Published Bulgaria 1995
Subjects
Animals
Atrial Natriuretic Factor - metabolism
Hypothalamus, Posterior - physiology
Male
Osmolar Concentration
Plasma Cells - drug effects
Plasma Substitutes - pharmacology
Rats
Rats, Wistar
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Summary:Acute blood volume expansion (AVE) is a potent stimulus for atrial natriuretic peptide (ANP) release. Since several central nervous structures are well known for their involvement in the regulation of fluid and electrolyte homeostasis and in the secretion of central ANP, we carried our experiments on 33 conscious Wistar rats in order to determine if the integrity of the supramammillary (SMA) hypothalamic area is essential for the peripheral ANP response to AVE. We performed stereotaxic electrolytic lesions of SMA in part of the animals. To obtain AVE we administered 2 mL saline/100 g b.m. for 2 minutes into v. jugularis through the chronically implanted venous catheters. Plasma ANP was assayed radioimmunologically. AVE significantly increased plasma ANP both in the intact animals and in the lesioned rats. This concluded that SMA is not involved in the regulation of peripheral ANP release during AVE.
ISSN:0323-9950