Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin)

Interleukin-1 (IL-1) now refers to a family of polypeptides which are produced by the host in response to injury, infection, and various immunological reactions. To date, two forms have been cloned but there are likely others. Recombinant IL-1s confirm the multiple and diverse biological properties...

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Bibliographic Details
Published inThe Year in immunology Vol. 2; p. 68
Main Author Dinarello, C A
Format Journal Article
LanguageEnglish
Published Switzerland 1986
Subjects
Acute-Phase Reaction - etiology
Amino Acid Sequence
Clone Cells - metabolism
Endothelium - cytology
Endothelium - drug effects
Fibroblasts - drug effects
Fibroblasts - metabolism
Fibrosis - metabolism
Glycoproteins - physiology
Humans
Interleukin-1 - analysis
Interleukin-1 - immunology
Interleukin-1 - isolation & purification
Interleukin-1 - physiology
Lymphocyte Activation
Recombinant Proteins - isolation & purification
Recombinant Proteins - physiology
Tumor Necrosis Factor-alpha
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Summary:Interleukin-1 (IL-1) now refers to a family of polypeptides which are produced by the host in response to injury, infection, and various immunological reactions. To date, two forms have been cloned but there are likely others. Recombinant IL-1s confirm the multiple and diverse biological properties that had been described previously using natural IL-1s. In this review, the cloning approaches for are discussed; in addition, the molecular control of IL-1 synthesis and processing are considered. The various biological activities of recombinant IL-1s are presented and are discussed regarding their clinical relevance. The multiple biological activities of recombinant tumor necrosis factor (cachectin) are compared to those of recombinant IL-1s.
ISSN:0256-2308