Monitoring of suppressor cell activity in nine renal transplant patients

Function of Concanavalin A generated suppressor cells was serially tested on lymphocytes stimulated by mitogens, by a pool of test cells different in HLA-ABC and -DR, and by the kidney donor's cells preserved in liquid nitrogen. In six patients whose lymphocytes had strong suppressor cell activ...

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Published inActa chirurgica Hungarica Vol. 25; no. 2; p. 119
Main Authors Petri, I, Kaiser, G, Csajbók, E, Szenohradszky, P, Petri, G
Format Journal Article
LanguageEnglish
Published Hungary 1984
Subjects
Humans
Kidney Transplantation
Monitoring, Physiologic - methods
T-Lymphocytes, Regulatory - immunology
Transplantation Immunology
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Summary:Function of Concanavalin A generated suppressor cells was serially tested on lymphocytes stimulated by mitogens, by a pool of test cells different in HLA-ABC and -DR, and by the kidney donor's cells preserved in liquid nitrogen. In six patients whose lymphocytes had strong suppressor cell activity, the kidney had a good function for 17-28 months (up to the time of the survey). In three patients who had practically no suppressor cell activity before and after transplantation, each kidney was rejected within 2-3 months. These observations are in accordance with recent experimental and clinical studies of other authors supporting the importance of suppressor cell activity in transplantation tolerance.
ISSN:0231-4614