Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat

Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with...

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Bibliographic Details
Published inIndian journal of physiology and pharmacology Vol. 27; no. 3; p. 241
Main Authors Gada, V P, Nandal, N V, Balsara, J J, Chandorkar, A G
Format Journal Article
LanguageEnglish
Published India 01.07.1983
Subjects
alpha-Methyltyrosine
Animals
Antipsychotic Agents - toxicity
Catalepsy - chemically induced
Chlorpromazine - toxicity
Dopamine - biosynthesis
Drug Synergism
Haloperidol - toxicity
Humans
Male
Methyltyrosines - toxicity
Molindone - toxicity
Rats
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Summary:Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with the neuroleptic for the postsynaptic striatal dopamine receptor sites with resultant potentiation of the neuroleptic-induced catalepsy.
ISSN:0019-5499