Relationship between testosterone and hepatic lipids in mature male bonnet monkeys, Macaca radiata (Geoffroy)

Administration of testosterone propionate (TP; 1 mg/kg body weight/day; im, for 30 days) to mature male bonnet monkeys, decreased total lipids, glyceride glycerol and cholesterol concentrations in hepatic tissue. The decrease in glyceride glycerol was due to decrease in monoacyl and triacyl glycerol...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 29; no. 12; p. 1140
Main Authors Jeyaraj, D A, Govindarajulu, P
Format Journal Article
LanguageEnglish
Published India 01.12.1991
Subjects
Animals
Lipid Metabolism
Liver - metabolism
Macaca radiata
Male
Testosterone - physiology
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Summary:Administration of testosterone propionate (TP; 1 mg/kg body weight/day; im, for 30 days) to mature male bonnet monkeys, decreased total lipids, glyceride glycerol and cholesterol concentrations in hepatic tissue. The decrease in glyceride glycerol was due to decrease in monoacyl and triacyl glycerol. Both, free and esterified cholesterol were decreased after testosterone administration. Eventhough, total phospholipid was not significantly altered, phosphatidylserine and cardiolipin were increased, due to testosterone administration. Testosterone inhibited NADP-isocitrate dehydrogenase activity in liver. The findings suggest that testosterone acts as a lipolytic hormone and its action may be direct through its specific receptors in liver.
ISSN:0019-5189