Heterogeneity in the plasma levels of two acute-phase proteins in mice from inbred strains infected with Trypanosoma cruzi

• Published in: Parasitology research (1987) Vol. 80; no. 5; p. 439
• Main Authors: Luz, M R, van Leuven, F, Araújo-Jorge, T C
• Format: Journal Article
• Language: English
• Published: Germany 1994
• Subjects: alpha-Macroglobulins - analysis; Animals; Blood Chemical Analysis; Chagas Disease - immunology; Chagas Disease - mortality; Genetic Variation; Male; Mice; Mice, Inbred BALB C - immunology; Mice, Inbred C3H - immunology; Mice, Inbred C57BL - immunology; Mice, Inbred Strains - immunology; Serum Amyloid P-Component - analysis; Time Factors
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/BF00932384

We analyzed the variations observed in the plasma levels of both alpha-macroglobulins (AM) and serum amyloid P (SAP) in mice from three different inbred strains (C3H, Balb/C and C57black/6) acutely infected with Trypanosoma cruzi. SAP levels increased in C57black/6 and Balb/C mice but not C3H mice. AM levels increased in all C3H mice but not in C57black/6 mice and rose slightly in only 43% of the Balb/C mice. AM and SAP levels are differently modulated in patterns that may be strain-determined.