Effect of Ha-ras on mitogen-induced Ca(2+)- and K(+)-fluxes

Transforming Ha-ras enhances the mitogen-induced activation of both the Ca(2+)-influx and the furosemide-sensitive Na+/K+/2Cl-cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.

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Bibliographic Details
Published inAdvances in enzyme regulation Vol. 32; pp. 163 - 176
Main Authors Grunicke, H, Maly, K, Meyer, M, Oberhuber, H, Bichler, I, Waldegger, L S, Woell, E, Lang, F
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
3T3 Cells
Animals
Biological Transport, Active - drug effects
Bombesin - pharmacology
Bradykinin - pharmacology
Calcium - metabolism
Cell Division - drug effects
Fibroblasts
Furosemide - pharmacology
Mice
Mitogens - pharmacology
Oncogene Protein p21(ras) - pharmacology
Potassium - metabolism
Rubidium - metabolism
Transfection
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Summary:Transforming Ha-ras enhances the mitogen-induced activation of both the Ca(2+)-influx and the furosemide-sensitive Na+/K+/2Cl-cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0065-2571
DOI:10.1016/0065-2571(92)90015-R