Longitudinal study of clinical, neurophysiological and immunological parameters in multiple sclerosis. Preliminary investigation

Thirty subjects affected with multiple sclerosis, of which 22 were female and eight male, with an average of 30 +/- 7, years were studied, for a period of 10-15 months,. clinically using Kurtzkes' report form, neurophysiologically (responses tested: VEP, BAEP, SEP, ESG) and immunologically (Ros...

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Bibliographic Details
Published inInternational journal on tissue reactions Vol. 3; no. 3-4; p. 177
Main Authors Gambi, D, Rossini, P M, Marchionno, L, Ricci, L, Barboni, F, Di Primio, R, Battista, P
Format Journal Article
LanguageEnglish
Published Switzerland 01.12.1981
Subjects
Adult
Evoked Potentials, Auditory
Evoked Potentials, Somatosensory
Evoked Potentials, Visual
Female
Humans
Inosine Pranobex - therapeutic use
Italy
Longitudinal Studies
Male
Multiple Sclerosis - drug therapy
Multiple Sclerosis - immunology
Multiple Sclerosis - physiopathology
Rosette Formation
Italy
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Summary:Thirty subjects affected with multiple sclerosis, of which 22 were female and eight male, with an average of 30 +/- 7, years were studied, for a period of 10-15 months,. clinically using Kurtzkes' report form, neurophysiologically (responses tested: VEP, BAEP, SEP, ESG) and immunologically (Rosette Et, Ea, EAC). Of the 30 cases, 19 showed poussées in the last three years and 11 were in the stabilization phase. The Kurtzke reports and the neurophysiological tests permitted an accurate assessment of lesion levels and their rate of evolution. The immunological tests showed a notable ability to differentiate between subjects with recent poussées and those in the stabilization phase presenting overall values significantly below the norm. In the follow-up, after treatments with methisoprinol, the immunological tests also revealed modifications of notable interest.
ISSN:0250-0868