Monitoring of plasma total antioxidant status in different diseases

The pathological increase of oxygen free radical generation has already been recognised in more than one hundred diseases. To gain information about the consequences of oxidative stress the investigation of plasma antioxidants seems to be plausible. In our study we used a new kit (RANDOX, England) f...

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Bibliographic Details
Published inActa chirurgica Hungarica Vol. 36; no. 1-4; p. 188
Main Authors Lantos, J, Röth, E, Czopf, L, Nemes, J, Gál, I
Format Journal Article
LanguageEnglish
Published Hungary 1997
Subjects
Antihypertensive Agents - therapeutic use
Antioxidants - analysis
Antioxidants - metabolism
Blood
Cardiovascular Agents - therapeutic use
Cholecystectomy
Cholecystectomy, Laparoscopic
Humans
Hypertension - blood
Myocardial Ischemia - blood
Myocardial Ischemia - drug therapy
Oxidative Stress
Reactive Oxygen Species - metabolism
Reproducibility of Results
Stress, Physiological - blood
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Summary:The pathological increase of oxygen free radical generation has already been recognised in more than one hundred diseases. To gain information about the consequences of oxidative stress the investigation of plasma antioxidants seems to be plausible. In our study we used a new kit (RANDOX, England) for measurement of total antioxidant status (TAS) to determine whether it has diagnostic value in comparison with our earlier results of measuring other parameters of oxidative stress in the following diseases: i./In the group of patients with ischemic heart disease (n = 19) the TAS elevated from 1.08 +/- 0.13 to 1.16 +/- 0.11 mM after 2 weeks of cardioprotective drug administration showing the beneficial effect of drug treatment. ii./In the group of patients with essential hypertension (n = 47) its values were below the normal range (1.11 +/- 0.15 mM) at the time of the first investigation and increased gradually following antihypertensive treatment. iii./The changes of TAS values of patients who underwent open (n = 21) or laparoscopic (n = 21) cholecystectomy indicated the less surgical trauma following laparoscopic procedures. Our results suggest that determination of TAS is a valuable and reproducible method to detect the actual antioxidant status in patients.
ISSN:0231-4614