Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. I. Antioxidant enzyme activities and lipid peroxidation

The influence of liposome-entrapped catalase and/or superoxide dismutase on bleomycin-induced rat lung injury was studied. Liposome-entrapped catalase and/or superoxide dismutase increase antioxidant enzyme activities in the lung tissue of bleomycin-treated rats. The level of lipid peroxidation prod...

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Bibliographic Details
Published inActa veterinaria Hungarica (Budapest. 1983) Vol. 39; no. 3-4; p. 215
Main Author Ledwozyw, A
Format Journal Article
LanguageEnglish
Published Hungary 1991
Subjects
Animals
Bleomycin - adverse effects
Catalase - administration & dosage
Catalase - metabolism
Drug Carriers
Lipid Peroxidation
Liposomes
Male
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - prevention & control
Rats
Rats, Inbred Strains
Superoxide Dismutase - administration & dosage
Superoxide Dismutase - metabolism
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Summary:The influence of liposome-entrapped catalase and/or superoxide dismutase on bleomycin-induced rat lung injury was studied. Liposome-entrapped catalase and/or superoxide dismutase increase antioxidant enzyme activities in the lung tissue of bleomycin-treated rats. The level of lipid peroxidation products (malondialdehyde, conjugated dienes, lipid hydroperoxides) was significantly lower in liposome-entrapped catalase and/or superoxide dismutase supplemented rats with bleomycin-injured lungs. It is suggested that liposomes are good vectors for drugs in the treatment of bleomycin-induced lung fibrosis.
ISSN:0236-6290