Incorporation of the antiherpetic 5-isopropyl-2'-deoxyuridine into a synthetic DNA and the consequence of incorporation on structure and functions of the DNA

5-Isopropyl-2'-deoxyuridine is the active ingredient of Hevizos ointment, a commercially available drug in Hungary, applied on the local treatment of patient with herpes labialis, zoster and progenitalis. The 5'-triphosphate derivative of the compound was incorporated by a DNA polymerase e...

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Bibliographic Details
Published inActa pharmaceutica Hungarica Vol. 63; no. 4; p. 204
Main Authors Sági, J, Szabolcs, A, Szemzö, A, Michaela, V, Jaroslav, K, Jitka, S, Alena, S, Otvös, L
Format Journal Article
LanguageHungarian
Published Hungary 01.07.1993
Subjects
Antiviral Agents - chemistry
Antiviral Agents - metabolism
Deoxyuridine - analogs & derivatives
Deoxyuridine - chemistry
Deoxyuridine - metabolism
DNA - chemistry
Microscopy, Electron
Molecular Structure
Nucleic Acid Conformation
Ointments
Poly dA-dT - chemistry
Poly dA-dT - metabolism
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Summary:5-Isopropyl-2'-deoxyuridine is the active ingredient of Hevizos ointment, a commercially available drug in Hungary, applied on the local treatment of patient with herpes labialis, zoster and progenitalis. The 5'-triphosphate derivative of the compound was incorporated by a DNA polymerase enzyme into a synthetic DNA of poly(dA-dT) type in order to study possible alterations in the structure and bioorganic functions of the DNA, in comparison with unmodified poly(dA-dT). Alterations observed by spectroscopic, electron microscopic and biochemical methods refer to the formation of stable hairpins protruding from the DNA duplex, which may be responsible for the impairment of the integrity of the DNA structure. This, in turn, may negatively influence normal biochemical functions of a DNA.
ISSN:0001-6659